By Yannis Alamanos, Alexandros A. Drosos (auth.), Manuel Ramos-Casals, John H. Stone, Haralampos M. Moutsopoulos (eds.)
Sjögren’s Syndrome: prognosis and Therapeutics presents an intensive, multisystemic evaluate of the medical manifestations of Sjögren’s Syndrome. It includes chapters pertinent around the diversity of clinical specialties that could come across Sjögren’s Syndrome circumstances. Chapters are specialty-specific, for simple reference by way of the correct clinical expert. as well as being a diagnostic consultant, Sjögren’s Syndrome: analysis and Therapeutics features a part on analysis and results of Sjögren’s Syndrome sufferers and offers an exhaustive healing replace, fascinated by new brokers and experimental techniques.
The inclusion of diagnostic/therapeutic algorithms illustrates the textual content with medical images of the most organs concerned and is helping the reader to make guided diagnostic and healing judgements via decision-based algorithms.
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Extra info for Sjögren’s Syndrome: Diagnosis and Therapeutics
Sample text
Mapping of the SS proteome holds significant promise for revealing valuable biomarkers useful in the diagnosis and classification of the disease. It also stands to aide in drug discovery and monitoring of treatment efficacy with the goal of early treatment to prevent disease progression. Recent studies aimed at cataloguing the normal human proteome have identified over 1,100 proteins in human saliva [55]. Multiple studies have evaluated the proteomes of whole saliva and minor salivary glands in SS [61–65].
Lefkowitz DL, Lefkowitz SS. Macrophage-neutrophil interaction: a paradigm for chronic inflammation revisited. Immunol Cell Biol. 2001;79:502–6. 32. Fox RI, Carstens SA, Fong S, et al. Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in Sjogren’s syndrome. Arthritis Rheum. 1982;25:419–26. 33. Fox RI, Kang HI, Ando D, et al. Cytokine mRNA expression in salivary gland biopsies of Sjogren’s syndrome. J Immunol. 1994;152:5532–9. 34. McGeehan GM, Becherer JD, Bast Jr RC, et al.
Each diamond represents the r2 values between any 2 SNPs. 99. 20. The shading of each diamond is proportional to the r2 value. 0) Haplotype Block: Alleles at neighboring SNPs are associated with alleles at disease SNP Causal Allele * * * *** * * * * * * * * * * * Positive association 1. Screen by GWAS 2. Identify association by LD 3. Genotype to fine map 4. Narrow region of association 5. Sequencing (identify new variants) Fig. 5 Mapping genetic effects in complex diseases. This figure illustrates the concept of mapping genetic associations within the genome.