By Raphael M. Ottenbrite
content material: Polymer structures for biomedical purposes : an summary / Raphael M. Ottenbrite and Natalya Fadeeva --
Bioelastic fabrics and the [delta]Tt-mechanism in drug supply / Dan W. Urry, D. Channe Gowda, Cynthia M. Harris, and R. Dean Harris --
Sequence-selective binding of DNA by way of oligopeptides as a singular method of drug layout / Moses Lee and Clint Walker --
Protein machine for glucose-sensitive unencumber of insulin / Y. Ito and Y. Imanishi --
guidance and characterization of enzyme-digestible hydrogels from ordinary polymers by way of gamma irradiation / Kalpana R. Kamath and Kinam Park --
Pharmacokinetics and toxicity of a p-boronophenylalanine-cyclodextrin formula added through intravenous infusion to canines / T.R. LaHann, W.F. Bauer, P. Gavin, and D.R. Lu --
Electrorelease of substances from composite polymer movies / Maria Hepel and Zbigniew Fijalek --
Pulsatile drug free up by means of electrical stimulus / You Han Bae, Ick Chan Kwon, and Sung Wan Kim --
Poly(ethylene oxide)-based supply structures : effect of polymer molecular weight and gel viscoelastic habit on drug free up mechanism / A. Apicella, B. Cappello, M.A. Del Nobile, M.I. l. a. Rotonda, G. Mensitieri, L. Nicolais, and S. Seccia --
improvement of micelle-forming polymeric drug with more advantageous anticancer job / M. Yokoyama, G.S. Kwon, T. Okano, Y. Sakurai, and okay. Kataoka --
Optimization of poly(maleic acid-alt-2-cyclohexyl-1,3-dioxepin-5-ene) for anti-human immunodeficiency virus job / Jian Ling Ding and Raphael M. Ottenbrite --
Enhancement of mobile membrane affinity and organic task of polyanionic polymers / Yasuo Suda, Shoichi Kusumoto, Naoto Oku, and Raphael M. Ottenbrite --
Accumulation of poly(vinyl alcohol) at inflammatory website / Tetsuji Yamaoka, Yasuhiko Tabata, and Yoshito Ikada --
layout of recent construction blocks in resorbable polymers : software in drug supply microspheres / Ann-Christine Albertsson, Anders Löfgren, Cecilia Sturesson, and Maria Sjöling --
Chain constitution and hydrolysis of nonalternating polyester amides / Kenneth E. Gonsalves and Xiaomao Chen --
Polymeric site-directed supply of misoprostol to the tummy / P.W. Collins, S.J. Tremont, W.E. Perkins, R.L. Fenton, M.P. McGrath, G.M. Wagner, A.F. Gasiecki, R.G. Bianchi, J.J. Casler, C.M. Ponte, J.C. Stolzenbach, P.H. Jones, and D. Forster --
Use of [alpha]-1,4-polygalactosamine as a service of macromolecular prodrug of 5-fluorouracil / Tatsuro Ouchi, Keigo Inosaka, and Yuichi Ohya --
Poly(methacrylic acid) hydrogels for rumen pass and the supply of oral vaccines to ruminants / T.L. Bowersock, W.S.W. Shalaby, W.E. Blevins, M. Levy, and Kinam Park --
Polymer-solvent interactions studied with computational chemistry / Samuel J. Lee and Kinam Park.
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They are known to bind specifically to 4 and 5 contiguous adenine-thymine (AT) base pairs, respectively, in the minor groove of double helical B - D N A (1,2,5). The sequence specificity is the result of hydrogen bonding, electrostatic attraction, and van der Waals interactions (3). 00/0 © 1994 American Chemical Society 30 POLYMERIC DRUGS AND DRUG ADMINISTRATION base pair by default (6,7). Thus substitution of a heterocycle that provides space and a hydrogen bond acceptor for G(2)-NH in the place of pyrrole rings should alter the strict A T binding preference to permit G C recognition (6,7).
Qualitatively, similar data have been obtained using methylene blue as the drug release model. This study was complicated, however, by an aggregation dependent absorption at the concentration range of interest. 0 4 6 8 Time in Days 10 Figure 4. 2μΙ~ This release is a limiting case due to the absence of reservoir depth, and the absence ester and carboxamide chemical clocks to sustain release. 3M. Discussion As illustrated by Figure 4, the property of an inverse temperature transition can be used to load an elastomeric polypeptide matrix with drug.
Harris, C. ; Harris, R. , Biopolymers 1992, 32, 1243-1250. ch003 Department of Chemistry, Furman University, Greenville, SC 29613 Recent interest in the development of sequence-specificDNAbinding agents as chemotherapeutic agents, structural probes of DNA, and artificial restriction enzymes has led to the development of minor groove DNA binding agents that recognize selective base sequences. A rational approach to the development of low molecular weight oligoimidazolecarboxamide and polymethylene linked analogs of distamycin targeted for long guanine-cytosine (GC) rich sequences of D N A are described.