By D. H. Wright (auth.), Professor Dr. med. Volker Diehl, Professor Dr. med. Michael Pfreundschuh, Dr. med. Dipl. Phys. Markus Loeffler (eds.)
In the sector of Hodgkin's lymphoma, many new facts were accumulated over the past decade either at the phone of beginning of this affliction and on more advantageous remedies to medication the vast majority of pa tients even within the complicated phases. for that reason, it sort of feels to be justi fied to collect those new information in a different quantity of modern Re sults in melanoma examine. This quantity summarizes the contribu tions provided on the First overseas Symposium on Hodgkin's illness that came about in Cologne (FRG) on October 2-3, 1988. there's little question that the Hodgkin and Reed-Sternberg (H and RS) cells and their versions signify the malignant inhabitants in Hodgkin's lymphoma; notwithstanding, there's nonetheless a fierce debate as to the prospective telephone of foundation of Hand RS cells. a number of the difficulties confounding previous study into this query have been with regards to the trouble or digital impossibility, of acquiring purified populations of Hand RS cells. many of the contemporary growth stems from the institution of everlasting phone strains of Hand RS cells in culture.
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Example text
On the other hand, there are cases of HD in which the B-cell lineage of the neoplastic cells clearly could be demonstrated. They expressed B-cell-associated antigens and had c10nally rearranged Ig H chain genes without rearrangement of TcR genes. This is a characteristic constellation in B-cell lymphomas. This genotypic pattern has been frequently described in cases of HD which exhibited clonal rearrangement. However, detailed immunophenotypic analysis was not given. Most of these cases had a high content of Hand SR cells (Linch et al.
It was striking to find two cases of Hodgkin's disease with CD8-positive and CD4-negative tumor cells. Because of these findings, it appears that Hodgkin's disease is heterogeneous. Five phenotypes can be distinguished (see Table 8). Correlation between Immunophenotype of Hand RS Cells and Histological Type of Hodgkin's Disease Attempts to correlate these phenotypes with morphological categories were not successful, with the exception of the lymphocyte predominance category. Popperna (1980) was the first to describe the presence of the B-cell-associated 1 chain in Hand RS cells in a single case of lymphocyte-predominant Hodgkin's disease.
Arch Pathol Lab Med 112: 139-142 Pelicci PG, Knowles DM, Favera RD (1985) Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes. J Exp Med 162: 1015-1024 Regula DP Jr, Hoppe RT, Weiss LM (1988) Nodular and diffuse types of lymphocytic predominance Hodgkin's disease. N Engl J Med 318: 214-219 Seif GSF, Spriggs AL (1967) Chromosome change in Hodgkin's disease. J Natl Cancer Inst 39: 557 Stein H, Uchanska-Ziegler B, Gerdes J, Ziegler A, Werner P (1982) Hodgkin and SternbergReed cells contain antigens specific to late cells of granulopoiesis.