By Barbara J. Bain(auth.)
UP-TO-DATE useful consultant TO LEUKAEMIA DIAGNOSIS
Written via a popular specialist this functional advisor were totally revised and up to date. The ebook covers fresh advances within the fields of immunophenotyping, cytogenetics and molecular genetics. It illustrates how laboratory thoughts are used for the analysis and type of leukaemia and comprises pictures of irregular cells to assist prognosis.
This fourth variation:
- Incorporates the options of the 2008 WHO category of Tumours of Haematopoietic and Lymphoid Tissues
- Includes three hundred top of the range complete color electronic photographs of irregular cells in leukaemia and lymphoma - 50 of that are thoroughly new
each haematologist and haematopathologist should still make a copy shut handy for fast reference.Content:
Chapter One the character of Leukaemia, Cytology, Cytochemistry and the FAB category of Acute Leukaemia (pages 1–63):
Chapter Immunophenotyping and Cytogenetic/Molecular Genetic research in Leukaemia and comparable stipulations (pages 64–113):
Chapter 3 Acute Leukaemia: Integration of Morphological, Immunophenotypic and Genetic info and the WHO type (pages 114–218):
Chapter 4 The Myelodysplastic Syndromes (pages 219–260):
Chapter 5 persistent Myeloid Leukaemias (pages 261–300):
Chapter Six Lymphoid Leukaemias of Mature T, B and normal Killer Cells (pages 301–376):
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Additional resources for Leukaemia Diagnosis, Fourth Edition
Sample text
When cells are relatively agranular, immunocytochemistry for mast cell tryptase is more sensitive than cytochemical staining (Fig. 55) [80]. They also express CD117. Langerhans cell leukaemia Rare cases of AML have leukaemic cells showing features of Langerhans cells [84] (Fig. 56). Such (b) cases may occur de novo but it is likely that cases resembling M5 AML supervening in Langerhans cell histiocytosis [85] also represent a leukaemia of Langerhans cells. The diagnosis is made by assessment of cytology and immunophenotype (CD1a is expressed) with the demonstration of Birbeck granules by ultrastructural examination providing a definitive diagnosis.
These classifications brought clarity to a previously confused area. The degree of standardization that was achieved within and between countries greatly improved communication between haematologists and provided a framework for the major advances that subsequently occurred in the genetics and molecular genetics of haematological neoplasms. No other proposed classification was so widely accepted nor stood the test of time. However, after several decades of dominance, the FAB classification is now being supplemented or replaced by the WHO classification.
In infants and children M7 AML may be associated with t(1;22)(p13;q13) (see page 152), and in adults, and to a lesser extent in children, a significant proportion of cases are associated with abnormalities of chromosome 3q21q26 and with loss or long arm deletion of chromosome 5 or 7 [64]. Karyotypic abnormalities are more often found in M7 than in other FAB categories of AML (with the exception of M3) and the abnormalities are more often complex [64]. GATA1 mutations are invariably present in Down syndrome-associated cases but are also sometimes seen in other cases [65].