Human Malignancies: New Approaches to Diagnosis and Therapy by T. L. J. Boehm (auth.), D. Drahovsky Prof. Dr. phil. nat.,

By T. L. J. Boehm (auth.), D. Drahovsky Prof. Dr. phil. nat., B. Kornhuber Prof. Dr. med. (eds.)

To scientists, oncology capacity examine at the illness of melanoma. the relationship among uncomplicated study and scientific oncology, even if, isn't continually very transparent. easy study occasionally seems to be an paintings that's practiced for its personal sake and in demand for its perfection. The clinician needs to interpret the problems addressed via uncomplicated study, as he's desirous to receive solutions to the questions that scientific oncology leaves open. those are, between others, questions as to the etiology and pathogenesis of neoplasma in people. inspite of all of the technological advances in past times 10 years, the tips for brand spanking new remedies of human leukemias and tumors are nonetheless unsatisfactory. The discussion among researchers and clinicians mustn't ever stop, in order that those questions will be formulated in this sort of manner that technological know-how are able to resolution them. either events may still cooperate each time this is often worthwhile and attainable. Prospectively deliberate medical trials at the analysis and remedy of neoplasias supply a very good chance for learn regarding sufferers. Tumor and/or blood exams run by way of reference laboratories on quite a few sufferers with an identical prognosis can result in clinically proper easy examine. utilizing medical experiences in easy learn courses allows us to track lacking items within the puzzle of melanoma and positioned them into place.

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1985 50 35 by both. Further analyses of this type, and throughout the course of the disease, are needed together with assessing therapy and its outcome in relation to the overall receptor status. The Detection of Micrometastases With recent advances in adjuvant therapy (Goldhirsch and Gelber 1986) it is extremely important to try to identify more accurately those patients who require such therapy commencing in the immediate post-initial diagnosis and treatment period. One approach to identifying various patient populations has involved the use of tumor markers, initially by their assay in serum and/or urine and, more recently, at the tissue level through the use of immunocytochemical techniques.

As already mentioned, these tumor markers are only partially tumor specific. Tumor types and their respective tumor markers are listed in Table 1. Several of the tumor markers listed in Table 1 can be classified as oncofetal antigens. To this group of tumor markers belong carcinoembryonic antigen (CEA) , a-fetoprotein (AFP) , various carbohydrate antigens, e. , the pancreatic oncofetal antigen, fetal ferritin, and others. The oncofetal antigens are physiologically produced during embryogenesis.

J PathoI142:221-229 Moll R, Franke WW (1986) Cytochemical cell typing of metastatic tumors according to their cytoskeletal proteins. In: Lapsis K, Liotta LA, Rabson AS, Nijhoff M (eds) Biochemistry and molecular genetics of cancer metastasis. The Hague Moll R, Franke WW, Schiller DL, Geiger B, Krepler R (1982) The catalogue of human cytokeratins. Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11-24 25 Nagle RB, Lucas DO, McDaniel KM, Clark VA, Schmalzel GM (1984) New evidence linking mammary and extra-mammary Paget cells to a common cell phenotype.

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