By Cherie H. Dunphy MD (auth.), Cherie H. Dunphy (eds.)
The Frozen part Library sequence presents concise, straight forward, web site particular handbooks which are good illustrated and spotlight the pitfalls, artifacts and differential analysis matters that come up within the moved quickly frozen part situation.
Frozen part Library: Lymph Nodes highlights the usefulness of thoughts reminiscent of contact practise cytology and tremendous needle aspiration (FNA) cytology, in addition to FNA biopsy. This fascicle additionally indicates right dealing with for next ancillary reviews, together with movement cytometric, cytogenetic, and molecular experiences. specified emphasis is given to the constraints of frozen part prognosis in lymph node pathology. All chapters are written by means of specialists of their fields and comprise the hottest clinical info. This ebook serves as a really resource for physicians within the frozen part room and in intra-operative session occasions facing, and attracted to, this very advanced box of diagnostic pathology. Frozen part Library: Lymph Nodes is of serious worth to pathologists, citizens, and fellows who diagnose pathologic procedures related to lymph nodes.
Cherie H. Dunphy, M.D. is Professor of Pathology and Laboratory drugs, govt Director of Hematopathology and Hematopathology Fellowship division of Pathology and Laboratory medication college of North Carolina Chapel Hill, NC.
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Extra info for Frozen Section Library: Lymph Nodes
Example text
CLL/SLL, MCL-classical and blastoid variants, BL-atypical and posttransplant cases, and ALCL) are demonstrated in Figs. 13, respectively. The accurate, reliable subclassification in these subtypes is due to the characteristic, uniform cytomorphology of the neoplastic cells and their unique, characteristic immunophenotypes. ] may also be performed on FNA specimens, as discussed in the appropriate section below. 8 FNA of small lymphocytic lymphoma: (a) Cytomorphology with a monotonous population of numerous predominantly small lymphocytes; (b, c) reveal flow cytograms in this case demonstrating coexpression of CD19 and kappa [(b) upper right hand box] and CD5 and CD20 [(c) upper right hand box].
The study evaluated 200 lymphocytes in each specimen by cytomorphology. All small-cell NHLs showed <40% large cells by CM and FC. Diffuse large B-cell lymphoma (DLBCL) demonstrated >40% large cells by FC (all cases) and by CM (67% cases). 13 FNA cytomorphology of CD30+ anaplastic large-cell lymphoma: Numerous abnormal lymphoid forms with occasional “wreath” and “doughnut” forms. 10% neoplastic cells. In conclusion, large-cell lymphoma and largecell transformation may be reliably diagnosed if >40% large cells are encountered.
The resemblance may even lead to confusion with small crushed fragments of normal or hyperplastic lymph node. In mediastinal and non-mediastinal sites, small, round, blue-cell tumors may also be confused with malignant lymphoma (see Fig. 6). Likewise, it may be quite difficult to distinguish metastatic carcinoma from anaplastic large-cell lymphoma, which is often known to demonstrate a cohesive, paracortical, and/or sinusoidal growth pattern in lymph nodes (see Fig. 13 in Chap. 2). 6 Frozen section of small, round, blue-cell tumor (Ewing sarcoma): Mimics malignant lymphoma with dyscohesive lymphoid-appearing cells.