By Edited by, Jean-Charles Sanchez, Garry L. Corthals, Denis F. Hochstrasser
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Extra resources for Biomedical Application of Proteomics
Example text
The introduction of recombinant antibody technologies, and in particular of antibody phage technology [117], has greatly facilitated the production of goodquality monoclonal antibodies without immunization. These technologies are particularly efficient when pure antigen preparations are available [118], but antibodies have also been generated from phage libraries against “difficult” antigens [46]. It is difficult to imagine that antibody-based chips may facilitate the study of the relative abundance of membrane proteins in different biological specimens [119].
In solid cancers, the most decisive prognostic factor is the result of the surgical resection – microscopically curative or not – information that cannot and never will be provided by a molecular pattern. Thus, and this is a significant boundary for biomedical application of proteomics, the analysis of diseased tissues or organs alone, for example with proteomics tools, will only provide part of the prognostic information. As a corollary of the above, molecular data have to be linked to personalized clinical information in prognostic and therapeutic biomedical research, including validation tasks.
They can alter local pH [24] and the concentration of nutrients and metabolites, increase interstitial pressure as a consequence of an expanding cellular volume and increased vascular permeability, and induce hypoxia by increasing local oxygen consumption [25]. The latter is particularly true of cells that are very metabolically active, such as those found in tumors. Furthermore, the oxygen delivery decreases parallel to an increase in diffusion distances between capillaries and the center of the expanding cell mass.