By Francesco Collamati
This thesis specializes in a singular radio-guided surgical procedure method for entire tumor resections. It describes all points of the intraoperative probe, in addition to trying out and simulation of the unconventional method. The presentation develops the method from the preliminary notion to life like feasibility reports which have been the topic of a statement of the yank Society of Nuclear medication. only a 12 months after finishing this paintings, the process has now been validated for the 1st time on a meningioma sufferer, confirming all the predictions made during this thesis.
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Med. 19(1), 23–28 (2005) 17. S. Bonzom, L. Ménard, S. A. Duval, R. Siebert, S. Palfi, L. Pinot, F. Lefebvre, Y. Charon, An intraoperative beta probe dedicated to glioma surgery : design and feasibility study. IEEE Trans. Nucl. Sci. 54(30), 30–41 (2007) 18 1 Introduction to Radioguided Surgery 18. F. Bogalhas, Y. -A. Duval, F. Lefebvre, S. Palfi, L. Pinot, R. Siebert, L. Ménard, Development of a positron probe for localization and excision of brain tumours during surgery. Phys. Med. Biol. 54, 4439–4453 (2009) 19.
Yablokov, Detection of scintillation light in liquid xenon by multipixel avalanche Geiger photodiode and wavelength shifter. J. Instrum. 5 (2010) References 51 3. M. Angelone, G. Battistoni, F. Bellini, V. Bocci, F. D. Lucia, R. Faccini, F. Ferroni, S. Fiore, M. Marafini, D. Materazzo, I. Mattei, S. Morganti, V. Patera, L. Piersanti, M. Pillon, L. Recchia, A. Russomando, A. Sarti, A. S. Camillocci, C. Voena, Properties of para -terphenyl as a detector for α, β and γ radiation 4. K. , Comparison of the Geant4 electromagnetic physics models against the NIST reference data.
A system of 4 phantoms, simulating cancerous residuals with different topologies, was developed by practicing holes in a Plexiglas plate. 1 mL volume phantom, referred to as “Residual”, has dimensions compatible with residuals well identified by the Nuclear Magnetic Resonance. To check the effect of the phantom depth on the probe response and resolution in distinguishing the residual edge, the other three cylindrical phantoms have the 40 3 Design and Tests of the Probe Fig. 12 The three first prototypes of probes reconstructed in FLUKA.