By Douglas J. Martin BS, Edward G. Randles PhD, Marina Ramirez-Alvarado PhD (auth.), Morie A. Gertz, S. Vincent Rajkumar (eds.)
An updated reference in this attention-grabbing set of advanced problems, this ebook good points the main accomplished concepts for diagnosing, classifying, imaging, treating, and coping with amyloidosis in a number of organ platforms. worthwhile to the spectrum of practitioners from citizens to sub-specialists, this booklet is a succinct authoritative textual content written via leaders within the box. The authors supply guideline on all kinds of amyloidosis - together with basic amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With crucial remedy algorithms, Amyloidosis: analysis and therapy is the gold-standard for all hematologists, oncologists, and internists taking good care of sufferers with this disease.
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67. Child JS, Levisman JA, Abbasi AS, MacAlpin RN. Echocardiographic manifestations of infiltrative cardiomyopathy. A report of seven cases due to amyloid. Chest 1976;70: 726–31. 68. Carroll JD, Gaasch WH, McAdam KP. Amyloid cardiomyopathy: characterization by a distinctive voltage/mass relation. Am J Cardiol. 1982;49:9–13. 69. Koyama J, Ray-Sequin PA, Falk RH. Prognostic significance of ultrasound myocardial tissue characterization in patients with cardiac amyloidosis. Circulation 2002;106: 556–61.
In the same line, Hartmann et al. showed that 99m Tc-PYP scintigraphy is not useful in screening patients for cardiac involvement in amyloidosis, but that first-pass studies yield valuable information about diastolic function impairment [38]. Beyond being used to image cardiac amyloidosis, radiolabeled phosphate derivates have also been reported to localize in extracardiac amyloid deposits, such as amyloid deposits in the bronchi [39], soft tissues [40], testicles [41], liver [42], and lungs [43].
However, the possibility to image myocardium with 99m Tc-(V)-DMSA is hampered by a strong signal from the blood pool. Radiolabeled β2 -Microglobulin Since conventional techniques, such as joint ultrasonography, X-ray, CT, or MRI, lack specificity in evaluating lesions caused by dialysis-related amyloidosis (Aβ2 m), imaging of β2 -microglobulin deposits has been attempted using β2 -microglobulin labeled with 131 I as a radiotracer [53–55]. Tracer accumulations correspond to the typical distribution pattern of Aβ2 m deposits [53, 54].